A Comparison of Arctic Ocean Sea Ice Export Between Nares Strait and the Canadian Arctic Archipelago

Nares Strait and the channels of the Canadian Arctic Archipelago (CAA) act as conduits for sea ice export from the Arctic Ocean but have never been directly compared. Here, we perform such a comparison for both the sea ice area and volume fluxes from October 2016 to December 2021. Nares Strait provided the largest average seasonal (October through September) ice area flux of 95 ± 8 × 103 km2 followed by the CAA regions of the Queen Elizabeth Islands (QEI) at 41 ± 7 × 103 km2 and M’Clure Strait at 2 ± 8 × 103 km2 with corresponding ice volume fluxes of 177 ± 15 km3, 59 ± 10 km3, and 8 ± 8 km3, respectively. Larger Arctic Ocean ice export at Nares Strait was associated with a shorter ice arch duration (237 days) compared to M’Clure Strait (163 days) and QEI (65 days). Seasonal Arctic Ocean ice export was dominated by Nares Strait in 2017–2019 and 2021 but was remarkably exceeded by the QEI in 2020. Large-scale atmospheric circulation patterns were found to influence the ice area flux in the absence of ice arches but no occurrence of coherent Arctic Ocean ice export events coinciding across all gates were observed. Average net seasonal Arctic Ocean ice area and volume export were 138 × 103 km2 and 245 km3, which represent ∼16% of the area and ∼25% of the volume of sea ice export from Fram Strait. Divergent Arctic Ocean export ice trajectories are apparent for Nares Strait and the QEI when compared to Fram Strait

Pursuing the Ephemeral, Painting the Enduring: Alzheimer\u27s and the Artwork of William Utermohlen

This book is published in conjunction with the exhibition Pursuing the Ephemeral, Painting the Enduring: Alzheimer’s and the Artwork of William Utermohlen, Exhibition and Scholarly Reflections presented at Illinois Wesleyan University Wakeley Gallery November 6 to December 11, 2015. The exhibition and catalogue are partially funded by a grant from the Andrew W. Mellon Foundation. William Utermohlen’s work is represented by Chris Boïcos Fine Arts, Paris and Jennifer Norback Fine Arts, Chicago.https://digitalcommons.iwu.edu/utermohlen/1000/thumbnail.jp

Fostering clinical reasoning in physiotherapy: Comparing the effects of concept map study and concept map completion after example study in novice and advanced learners

Background: Health profession learners can foster clinical reasoning by studying worked examples presenting fully worked out solutions to a clinical problem. It is possible to improve the learning effect of these worked examples by combining them with other learning activities based on con

Immunoseq: the identification of functionally relevant variants through targeted capture and sequencing of active regulatory regions in human immune cells

$\textbf{BACKGROUND}$: The observation that the genetic variants identified in genome-wide association studies (GWAS) frequently lie in non-coding regions of the genome that contain cis-regulatory elements suggests that altered gene expression underlies the development of many complex traits. In order to efficiently make a comprehensive assessment of the impact of non-coding genetic variation in immune related diseases we emulated the whole-exome sequencing paradigm and developed a custom capture panel for the known DNase I hypersensitive site (DHS) in immune cells - "Immunoseq". $\textbf{RESULTS}$: We performed Immunoseq in 30 healthy individuals where we had existing transcriptome data from T cells. We identified a large number of novel non-coding variants in these samples. Relying on allele specific expression measurements, we also showed that our selected capture regions are enriched for functional variants that have an impact on differential allelic gene expression. The results from a replication set with 180 samples confirmed our observations. $\textbf{CONCLUSIONS}$: We show that Immunoseq is a powerful approach to detect novel rare variants in regulatory regions. We also demonstrate that these novel variants have a potential functional role in immune cells.This work was supported by grants from the Canadian Institute of Health Research (CIHR), the UK Medical Research Council (G1100125), the Swedish Research Council (DO283001) and Knut and Alice Wallenberg Foundation (KAW). We also acknowledge the use of subjects from the Cambridge BioResource and the support of the Cambridge NIHR Biomedical Research Centre. AM was supported by the Fond de Recherche Santé Québec Doctoral training award. TP and CL holds a Canada Research Chair

Divergence and convergence of policy priorities among sub-national units in federal systems: the cases of Canada and Spain

The study of policy dynamics at the sub-national level in federal systems is getting growing attention by scholars of comparative politics and agenda- setting. These studies analyze to what extent the political agendas of regional governments are converging or diverging over time, focusing on: institutional factors (e.g., formal rules defining issue jurisdiction, type of government, intergovernmental arrangements), preferences (mostly of political parties), and agenda capacity (Hooghe et al. 2008). This constitutes an important change from previous analysis on comparative federalism, which traditionally focused on institutions as explanatory variable, providing a static outlook on the vertical distribution of authority between levels of government (Wibbels 2003). It also constitutes an important change in relation to another set of studies (Filippov et al. 2004; Wibbels 2006; Aldrich 1995) that pay attention to party politics and policy preferences, but still deal mainly with the relationship between the national and regional governments as a whole (e.g., Constantelos 2010). Finally, analyses of issue prioritization at the sub-national level (and the relations with the national and supranational level of governance) also make a ontribution to the policy [...]

Regulating Assisted Reproduction in Canada, Switzerland, and the USA: Comparing the Judicialization of Policy-making

This article analyses the extent to which courts shape policies for assisted reproduction. While the USA is considered to be the most litigious country, Canada has observed a growing involvement of the courts from the 1980’s onward, and Switzerland is characterized by a modest degree of judicialization. Based on national patterns, we would expect litigation and court impact to vary across these three countries. As this paper demonstrates, policy-process specific variables such as the structure of policy conflicts, the novelty of regulation, self-regulation by key stakeholders, and the policies in place better explain the variation in the judicialization of policy-making

An Extremes of outcome strategy provides evidence that multiple sclerosis severity is determined by alleles at the <i>HLA-DRB1</i> locus

Multiple sclerosis (MS) is a common inflammatory disease of the central nervous system unsurpassed for variability in disease outcome. A cohort of sporadic MS cases (n=63), taken from opposite extremes of the distribution of long-term outcome, was used to determine the role of the HLA-DRB1 locus on MS disease severity. Genotyping sets of benign and malignant MS patients showed that HLA-DRB1*01 was significantly underrepresented in malignant compared with benign cases. This allele appears to attenuate the progressive disability that characterizes MS in the long term. The observation was doubly replicated in (i) Sardinian benign and malignant patients and (ii) a cohort of affected sibling pairs discordant for HLA-DRB1*01. Among the latter, mean disability progression indices were significantly lower in those carrying the HLA-DRB1*01 allele compared with their disease-concordant siblings who did not. The findings were additionally supported by similar transmission distortion of HLA-DRB1*04 subtypes closely related to HLA-DRB1*01. The protective effect of HLA-DRB1*01 in sibling pairs may result from a specific epistatic interaction with the susceptibility allele HLA-DRB1*1501. A high-density (&gt;700) SNP examination of the MHC region in the benign and malignant patients could not identify variants differing significantly between the two groups, suggesting that HLA-DRB1 may itself be the disease-modifying locus. We conclude that HLA-DRB1*01, previously implicated in disease resistance, acts as an independent modifier of disease progression. These results closely link susceptibility to long-term outcome in MS, suggesting that shared quantitative MHC-based mechanisms are common to both, emphasizing the central role of this region in pathogenesis

Learning in the European Union: Theoretical Lenses and Meta-Theory

notes: This paper is based on research carried out with the support of the European Research Council grant on Analysis of Learning in Regulatory Governance, ALREG http://centres.exeter.ac.uk/ceg/research/ALREG/index.php. The authors wish to express their gratitude to the other authors in this special edition and in particular its editor, Nikos Zaharaidis and X anonymous referees.publication-status: AcceptedThe European Union may well be a learning organization, yet there is still confusion about the nature of learning, its causal structure and the normative implications. In this article we select four perspectives that address complexity, governance, the agency-structure nexus, and how learning occurs or may be blocked by institutional features. They are transactional theory, purposeful opportunism, experimental governance, and the joint decision trap. We use the four cases to investigate how history and disciplinary traditions inform theory; the core causal arguments about learning; the normative implications of the analysis; the types of learning that are theoretically predicted; the meta-theoretical aspects and the lessons for better theories of the policy process and political scientists more generally